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Fig. 3 | Molecular Brain

Fig. 3

From: Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer’s disease

Fig. 3

FNDC5 binds APP at the domain of Aβ sequence on N-terminus. The differential affinities of FNDC5 for C99 and C83 were indicated in (a, b). The immunoprecipitated band indicating the interaction between FNDC5 and C83 was not detected. C99 and C83 were detected by Anti-Myc antibody, and FNDC5 was detected by anti-HA antibody. c shows that the immunoprecipitated band between APP full length and FNDC5 is decreased with the treatment of Aβ1–16 peptides. For the treatment of Aβ1–16 (−), the reverse peptide, Aβ16–1 was used as a control

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Molecular Brain

ISSN: 1756-6606