Fig. 3
From: Development of a peptide targeting dopamine transporter to improve ADHD-like deficits
The stimulant effect of D2R-DAT disruption is due to the rise of extracellular dopamine level in SD rats. a Schematic illustration and cresyl violet staining confirmation of cannula placement into both the lateral ventricle and nucleus accumbens core. The grey bars represent the cannula, whereas the black bar represents the 2-mm probe membrane. b Time-course raw traces of high performance liquid chromatography before and after the administration of TAT-DATNT was illustrated. The retention time of dopamine was determined to be at 5.08 min. c TAT-DATNT (40 nmol, i.c.v.) started to increase the extracellular dopamine level half an hour after its administration and such effect remained significant approximately for 2 hours (n = 5–6). The dotted line represented the time of intra-cranial injection. All data were presented as percent dopamine to baseline (%) ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001