Fig. 1
From: Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex
Immunoblots of whole lysates from Syn1-Cre x Tsc1fl/fl mouse visual cortex. a. Representative immunoblots of GluA1, GluA2, GABAAR-α, phosphor-S6 and transferrin receptor are shown. Whole lysates were prepared from the visual cortex at P28. An increase in phosphor-S6 level indicates the overactivation of the mTOR pathway in a Syn1-Cre x Tsc1fl/fl mouse brain. b, c, d Band intensities of GluA1, GluA2 and GABAAR-α are normalized to actin. The mutant brains showed significant reductions in GluA1, GluA2 and GABAAR-α band intensities. * P < 0.05 in (b) and (c). ** P < 0.01 in (d). Error bars represent s.e.m. in (b), (c) and (d)