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Fig. 5 | Molecular Brain

Fig. 5

From: DA-JC1 improves learning and memory by antagonizing Aβ31–35-induced circadian rhythm disorder

Fig. 5

The role of Per2 interference using lentivirus on circadian rhythm disorder in mice. (a) A laser scanning confocal microscope was used to observe the GFP-positive cells. Scale bar = 100 μm. (n = 3 per group). (b) Representative Western blot and quantification analysis showing the protein expression of Per2. (n = 5 per group). (c) Representative locomotor activity records of each group and the free-running period of the locomotor activity rhythm in each group. (n = 5 per group). (d) The point-by-point average activity in DD of all the mice at each one-hour interval in the actogram. (n = 5 per group). Data are expressed as means ± SEM. *P < 0.05 compared with the control group

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