Fig. 3
From: Gene expression meta-analysis of Parkinson’s disease and its relationship with Alzheimer’s disease
Protein-protein interaction subnetwork created using the first neighbour nodes of the 14–3-3 protein family in the DEG PPIN. Six 14–3-3 family genes, YWHAZ, YWHAB, YWHAG, YWHAE, YWHAQ and YWHAH, were in the top 10 hubs for the subnetwork created from the top 30 DEGs found in our PD meta-analysis. A subnetwork of these 14–3-3 family members and their first neighbours were created. There were 18 DEGs that mapped to this, with red nodes indicating upregulated genes and green nodes indicating downregulated genes. Blue nodes indicate 14–3-3 family members that are not PD DEGs. Octagons denote genes that were in the top 30 DEGs. This first neighbour network contains 139 nodes and 539 edges