Fig. 7

Auditory brainstem response (ABR) of Lamp5 KO mice. a Representative ABR waveform to 12 kHz tone-burst stimuli recorded from wild type and a Lamp5 KO. b ABR threshold. Two-way repeated-measures ANOVA (genotype × frequency) revealed a significant main effect of frequency (F_(3,36) = 57.68, p < 0.0001), a non significant effect of genotype (F_(1,12) = 0.0124, p = 0.9133) and a significant interaction between factors (F_(3,36) = 2.921, p = 0.0471). Post-hoc Welch’s t-test revealed no significant difference between genotypes at either frequency (n = 7 for each genotype). c Amplitude of ABR waves at 16 kHz. The waves were indicated in a. Two-way repeated-measures ANOVA (genotype × sound intensity) and post-hoc Welch’s t-test were performed for each wave. A significant main effect of genotype and a significant interaction between factors were present in wave I (F_(1,12) = 10.15, p = 0.0078; F_(3,36) = 2.301, p = 0.0936, respectively), wave II (F_(1,12) = 8.977, p = 0.0111; F_(3,36) = 4.062, p = 0.0139, respectively) and wave V (F_(1,12) = 16.19, p = 0.0017; F_(3,36) = 5.341, p = 0.0038, respectively). * p < 0.05, ** p < 0.01, *** p < 0.001. Error bars indicate SEM