Fig. 5
From: Sacs R272C missense homozygous mice develop an ataxia phenotype
Presence of somatodendritic NFH bundles in brains of SacsR272C and Sacs−/− mice. (a-l) Immunohistochemistry using pan-NFH antibody on sagittal brain sections from 300 day-old mice demonstrate a strong NFH labeling in the cell bodies and dendrites of several CNS neuronal populations. Among others, accumulations of NFH protein in the somatodendritic area are seen in SacsR272C and Sacs−/− cerebellar PC (arrow in b and c), layer 2–3 and 5 cortical neurons (e, f) CA1, CA2 and CA3 hippocampal pyramidal neurons (arrows in h and i) and neurons in the thalamus (surrounded area in k and l). A decrease in NFH immunolabeling in the dentate gyrus molecular layer (mo) representing the axonal projections from the entorhinal cortex is observed in the SacsR272C and Sacs−/− mice (asterisk in h and i) compared to control animals (g). Scale bar in L = 200 μm