Fig. 8
From: Sacs R272C missense homozygous mice develop an ataxia phenotype
Mutant sacsin expression in SacsR272C mice. (a-f) Immunohistochemistry using antibody against sacsin on sagittal brain sections from 300 day-old SacsWT, SacsR272C and Sacs−/− mice demonstrate that some neuronal population express low levels of mutated sacsin. R272C mutant mice display an important reduction in sacsin immunolabeling in all areas of the brain, but labeling can still be observed in the cell bodies and dendrites of cerebellar PC (arrows in b1) and cell bodies of DCN neurons (arrows in b2). Scale bar in c2 = 200 μm, scale bar in F = 100 μm