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Fig. 1 | Molecular Brain

Fig. 1

From: Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses

Fig. 1

mGluR5 KO mice are impaired in the reversal phase of the touchscreen VDR task. a Images of the ‘marble’ and ‘fan’ stimuli used in the VDR task. b Mean number of sessions required to reach the VDR acquisition criterion (> 80% correct responses for 2 consecutive days). c-d Mean response latency and mean reward collection latency across VDR acquisition sessions. e Percentage of correct during 3 baseline training sessions (b1-b3) and following contingency reversal sessions (Two-way RM ANOVA, main effect of genotype; **p = 0.002). f-g Response latency and reward collection latency through the reversal sessions. h Accumulated errors to reach 50% correct (early phase) in reversal learning (Unpaired t test; *p = 0.037). WT group n = 7 and mGluR5 KO group n = 7. All data are presented as means ± s.e.m

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Molecular Brain

ISSN: 1756-6606