Skip to main content
Fig. 2 | Molecular Brain

Fig. 2

From: Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses

Fig. 2

mGluR5 genetic ablation and pharmacological antagonism impair extinction performance in mice. a Mean number of sessions required to reach criterion (completion of 30 trials within 12.5 min for 5 consecutive days). WT group n = 8 and mGluR5 KO group n = 8. b Single-session analysis (1st session) of the first 3 min of extinction task (Two-way RM ANOVA, main effect of genotype; **p = 0.006). c Number of correct responses before making 3 consecutive omissions (Unpaired t test; *p = 0.012). d Single-session analysis (1st session) of the first 3 min of extinction task (Two-way RM ANOVA, main effect of genotype; *p = 0.032). MTEP-treated group n = 8 and vehicle-treated group n = 8. e Number of correct responses before making 3 consecutive omissions (Unpaired t test; *p = 0.027). All data are presented as means ± s.e.m.

Back to article page

Molecular Brain

ISSN: 1756-6606