Fig. 1

Timeline of PTSD-like model construction and behavior tests. C57BL/6J mice at 8–10 weeks of age were subjected to acclimation followed by electric foot shock. The control mice underwent the same acclimation procedure without foot shock. Avoidance test and situational reminder (AV/SR) were weekly performed, and the freezing test was done at 5 weeks post stress (PS). Open field test (OF) and elevated plus maze test (EPM) were performed at 2 weeks and 4 weeks PS. Light/dark box test (LDB) was performed around 4 weeks PS. Acoustic startle response test (ASR) was performed around 2 weeks and 4 weeks PS, and locomotive activity test were carried out from 4 weeks to 5 weeks PS