Fig. 2From: Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male miceFluoxetine induces an increase in the number of inhibitory inputs to excitatory neurons and reduced excitatory basal transmission in the L5 pyramidal neurons of the prelimbic cortex of FLX-treated mice. (a) Representative current traces depicting spontaneous excitatory post-synaptic currents (sEPSCs) obtained from L5 pyramidal neurons in the prelimbic cortex (PrL) pyramidal neurons of SAL- and FLX-treated (red) mice. (b and c) Plots of the cumulative distributions of sEPSC (b) amplitudes and (c) inter-event intervals obtained from SAL- (black) and FLX-treated (red) mice. (d) Representative current traces depicting mEPSCs obtained from SAL- and FLX-treated mice. (e and f) Plots of the cumulative distribution plots of mEPSC (e) amplitudes and (f) inter-event intervals. (g) Representative current traces depicting sIPSCs obtained from SAL- and FLX-treated mice. (h and i) Plots of the cumulative distribution plots of sIPSC (h) amplitudes and (i) inter-event intervals. (j) Representative current traces depicting mIPSCs obtained from SAL- and FLX-treated mice. (k and l) Plots of the cumulative distribution of mIPSC (k) amplitudes and (l) inter-event intervals. Data are presented as mean ± SEM. All data were analyzed using the Mann-Whitney U test. *p < 0.05, **p < 0.01Back to article page