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Fig. 2 | Molecular Brain

Fig. 2

From: Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice

Fig. 2

Fluoxetine induces an increase in the number of inhibitory inputs to excitatory neurons and reduced excitatory basal transmission in the L5 pyramidal neurons of the prelimbic cortex of FLX-treated mice. (a) Representative current traces depicting spontaneous excitatory post-synaptic currents (sEPSCs) obtained from L5 pyramidal neurons in the prelimbic cortex (PrL) pyramidal neurons of SAL- and FLX-treated (red) mice. (b and c) Plots of the cumulative distributions of sEPSC (b) amplitudes and (c) inter-event intervals obtained from SAL- (black) and FLX-treated (red) mice. (d) Representative current traces depicting mEPSCs obtained from SAL- and FLX-treated mice. (e and f) Plots of the cumulative distribution plots of mEPSC (e) amplitudes and (f) inter-event intervals. (g) Representative current traces depicting sIPSCs obtained from SAL- and FLX-treated mice. (h and i) Plots of the cumulative distribution plots of sIPSC (h) amplitudes and (i) inter-event intervals. (j) Representative current traces depicting mIPSCs obtained from SAL- and FLX-treated mice. (k and l) Plots of the cumulative distribution of mIPSC (k) amplitudes and (l) inter-event intervals. Data are presented as mean ± SEM. All data were analyzed using the Mann-Whitney U test. *p < 0.05, **p < 0.01

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