Fig. 3

CTEP facilitates CREB-mediated expression of BDNF in zQ175 mice. a Representative western blots and mean ± SEM of CREB-pS133 (b) cFos and (c) BDNF in brain lysates from homozygous zQ175 and wildtype (WT) mice after chronic treatment with either vehicle or CTEP (2 mg/kg). Values are expressed as a fraction of the vehicle-treated WT. CREB-pS133 was normalized to total CREB, cFos was normalized to vinculin expression and BDNF was normalized to actin expression (n = 5–6 for each group). Representatives for each panel were obtained from the same blot. P < 0.05 * significantly different from vehicle-treated zQ175 mice and ^# P < 0.05 significantly different from vehicle-treated WT mice