Fig. 7
Role of C-terminus on Cav3.3 gating currents. a Representative gating current traces recorded from cells expressing the various Cav3.3 variants. Each trace represents an average of five traces recorded during cell depolarization to its reversal potential. Below each current trace is a depiction of time courses of integrals calculated for that trace. Current traces and integrals are scaled to 1 for a better comparison. Grey lines represent the integral of the gating current trace for the WT channel. b Corresponding mean Gmax/Qrev ratios calculated for each investigated cell. c Corresponding mean 10–90% rise times calculated from the integral time course shown in panel a