Fig. 6
From: A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
Depotentiation and LTD of CKO mice was impaired. a Stable LTP was produced by 4 × TBS in both Cont and CKO mice, but LFS did not induce a reversal of LTP in CKO mice (N = 3/group, n = 7/group). b Waves of the last 10 min on the phases of baseline (1, black), LTP induced by 4 × TBS (2, black) and reversal LTP induced by LFS (3, red). The line of Cont group was black and that of CKO group was gray. c LTD could be induced by LFS in Cont mice but not in CKO mice. Meanwhile, LFS-induced LTD was significantly blocked by the PP2A inhibitor (Cont group: N = 3, n = 7, CKO group: N = 3, n = 7, Cont+OA group: N = 4, n = 6). d Waves of the last 10 min on the phases of baseline (1, black) and LTD induced by LFS (2, black). The line of Cont group was black and that of CKO group and Cont+OA group were gray and blue. Vertical scale bar represents 0.2 mV; horizontal scale bar represents 50 ms. * p < 0.05, *** p < 0.001