Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset

Table 2 Comparison of fluoxetine-induced effects on cell maturity and neurogenesis in rodents and marmosets

Region	Marker		Rodents^*1	Marmosets^*2
Dentate gyrus	Cell maturity	CR (immature)	Increase [10, 12]	Increase
		DCX (immature)	Increase [17]	Increase
		CB (mature)	Decrease [10, 18]	Not significant
		PV/PNN (mature fast-spiking cells)	Decrease [12]	Decrease
	Neurogenesis	BrdU (proliferation)	Increase [5,6,7]	Not significant
Cerebral cortex	Cell maturity	PV/PNN (mature fast-spiking cells)	Decrease [12]	Not significant
	Neurogenesis	Ki67/GAD67 (L1-INP cells)	Increase [9]	Increase (non-significant)^*3
	Neurogenesis	BrdU/GAD67 (new interneurons)	Increase [9]	Increase
Amygdala	Cell maturity	PNN/PV (mature fast-spiking cells)	Decrease [11, 12]	Not significant
SVZ	Neurogenesis	BrdU or Ki67 (proliferation)	Decrease [15]	Unknown

CR Calretinin, DCX Doublecortin, CB Calbindin, PV Parvalbumin, PNN Perineuronal net, BrdU Bromodeoxyuridine, GAD67 Glutamate decarboxylase 67, SVZ Subventricular zone. ^*1Fluoxetine dosage: 10–18 mg/kg/day; ^*2fluoxetine dosage: 3 mg/kg/day; ^*3P = 0.098

ISSN: 1756-6606