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Table 2 Comparison of fluoxetine-induced effects on cell maturity and neurogenesis in rodents and marmosets

From: Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset

Region Marker Rodents*1 Marmosets*2
Dentate gyrus Cell maturity CR (immature) Increase [10, 12] Increase
DCX (immature) Increase [17] Increase
CB (mature) Decrease [10, 18] Not significant
PV/PNN (mature fast-spiking cells) Decrease [12] Decrease
Neurogenesis BrdU (proliferation) Increase [5,6,7] Not significant
Cerebral cortex Cell maturity PV/PNN (mature fast-spiking cells) Decrease [12] Not significant
Neurogenesis Ki67/GAD67 (L1-INP cells) Increase [9] Increase (non-significant)*3
BrdU/GAD67 (new interneurons) Increase [9] Increase
Amygdala Cell maturity PNN/PV (mature fast-spiking cells) Decrease [11, 12] Not significant
SVZ Neurogenesis BrdU or Ki67 (proliferation) Decrease [15] Unknown
  1. CR Calretinin, DCX Doublecortin, CB Calbindin, PV Parvalbumin, PNN Perineuronal net, BrdU Bromodeoxyuridine, GAD67 Glutamate decarboxylase 67, SVZ Subventricular zone. *1Fluoxetine dosage: 10–18 mg/kg/day; *2fluoxetine dosage: 3 mg/kg/day; *3P = 0.098