Anterior insular cortex mediates hyperalgesia induced by chronic pancreatitis in rats

Table 2 Summary of membrane properties of insular pyramidal neurons in sham and CP rats

	Sham group	CP group	P
Passive membrane properties
Resting potential (mV)	−70.30 ± 1.48	−65.67 ± 1.42	0.048
Membrane resistance (MΩ)	225.8 ± 30.84	201.33 ± 22.35	n.s.
Access resistance (MΩ)	23.44 ± 1.34	23.13 ± 2.00	n.s.
Membrane time constant (ms)	2.07 ± 0.26	1.89 ± 0.25	n.s.
Active membrane properties
Current threshold (pA)	120.67 ± 19.65	74.33 ± 8.60	0.038
Voltage threshold (mV)	−38.54 ± 1.17	−39.45 ± 1.32	n.s.
AP amplitude (mV)	82.91 ± 2.31	83.84 ± 1.27	n.s.
AP rise slope (mV/ms)	132.90 ± 4.79	123.22 ± 5.15	n.s.
AP decay slope (mV/ms)	−46.00 ± 3.83	− 61.29 ± 4.11	0.021
AP latency (ms)	219.92 ± 41.45	384.42 ± 85.92	n.s.
Cell capacitance (pF)	82.81 ± 9.72	69.75 ± 7.11	n.s.

Values are means ± SEM. The level of significance was determined using Student’s unpaired t test. P values for the comparison of insular pyramidal neurons in sham and CP rats

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