Fig. 1

Distribution of proteins of C17.2 cells detected by LC/MS-MS. a - b Viability of c17.2 cells after berberine (BBR) and corticosterone (CORT) treatment using MTT assay. The data are shown as the means ± S.E.M from 6 independent experiments (n = 6). # vs. control groups, P < 0.05. ## vs. control groups, P < 0.01. VC: vehicle control. c - d General statistics of protein detected after CORT administration. Up: up-regulation of protein compared with normal control. Down: down-regulation of protein compared with normal groups. Negative means there were no obvious change of protein level compared with normal groups. The number on each bar of d indicates the number of proteins detected. e Effect of BBR on the up-regulated proteins induced by CORT. BBR to normal: BBR suppressed the upregulated protein to normal level compared with normal control. BBR to up: BBR acted the upregulated proteins but also in high level. BBR negative: No effect of BBR on the upregulated protein induced by CORT. f Effect of BBR on the down-regulated proteins induced by CORT. BBR to normal: BBR enhanced the down-regulated protein to normal level compared with normal control. BBR to up: BBR acted the down-regulated proteins in high level. BBR negative: No effect of BBR on the down-regulated protein induced by CORT