Table 5 Comparison of the slope factor (k) values (mV) for steady state activation and steady state inactivation curves with and without TNF-α
steady state activation k factor | steady state inactivation k factor | |||||
|---|---|---|---|---|---|---|
INa Total | INa TTXs | INa TTXr | INa Total | INa TTXs | INa TTXr | |
Control | 7.2 ± 0.4 n = 8 | 6.3 ± 0.5 n = 6 | 6.8 ± 0.5 n = 8 | − 5.1 ± 0.2 n = 7 | −4.8 ± 0.2 n = 6 | −5.9 ± 0.1 n = 6 |
+ TNF | 5.3 ± 0.2* n = 14 | 4.8 ± 0.3* n = 11 | 5.3 ± 0.8 n = 15 | −5.0 ± 0.3 n = 6 | −4.7 ± 0.4 n = 4 | −5.2 ± 0.5 n = 4 |
p value | < 0.001 | 0.0012 | 0.5598 | 0.3861 | 0.7267 | 0.2197 |