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Fig. 5 | Molecular Brain

Fig. 5

From: A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity

Fig. 5

Homology model of human Cav3.2. a Cartoon representation of secondary structural elements of human Cav3.2 (Uniprot O95180) homology model (residues 97–1974) based on Cav3.1 (PDB: 6KZO), showing side (left panel) and bottom (right panel) views of the channel. The four domains of Cav3.2 are colored in red, yellow, blue and green. The S1-S6 helices are indicated in red for domain I. Some of the flexible loops connecting the transmembrane helices are not shown, or could not be modeled, due to poor model accuracy or lack of structural information, respectively. The isoleucine 153 (Ile153) is shown in black. b Stereo diagram of Ile153 and nearby hydrophobic residues showing its involvement in the helical packing

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