Brain region | WT-VSV | Mutant-VSV |
---|
3 DPI | 5 DPI | 3 DPI | 5 DPI | 10 DPI |
---|
AON | + | ++ | + | ++ | ++ |
LS | + | ++ | + | ++ | ++ |
ACB (NAc) | + | ++ | + | + | ++++ |
CP | ++ | ++ | – | – | ++++ |
OT | – | + | – | – | +++ |
BST | + | ++ | + | + | ++++ |
Habenula | ++ | +++ | + | ++ | ++ |
Amygdala | + | ++ | – | – | +++ |
DR | + | ++ | + | + | ++ |
PIR | – | ++ | – | – | ++ |
PFC | – | – | – | – | + |
ACA | – | – | – | – | ++ |
MO | – | – | – | – | ++ |
SC | – | – | – | – | ++ |
SOC | – | – | – | – | ++ |
- The absence or presence of labeling was indicated by (−) and (+), respectively. The extent of labeling was indicated with the number of (+). Results showed that with the reduced toxicity and extended animal survival, more connected downstream networks were labeled by the Mutant-VSV compared with the WT-VSV