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Table 1 Assessment of viral spread from WT-VSV and Mutant-VSV injections into the VTA

From: A mutant vesicular stomatitis virus with reduced cytotoxicity and enhanced anterograde trans-synaptic efficiency

Brain region

WT-VSV

Mutant-VSV

3 DPI

5 DPI

3 DPI

5 DPI

10 DPI

AON

+

++

+

++

++

LS

+

++

+

++

++

ACB (NAc)

+

++

+

+

++++

CP

++

++

–

–

++++

OT

–

+

–

–

+++

BST

+

++

+

+

++++

Habenula

++

+++

+

++

++

Amygdala

+

++

–

–

+++

DR

+

++

+

+

++

PIR

–

++

–

–

++

PFC

–

–

–

–

+

ACA

–

–

–

–

++

MO

–

–

–

–

++

SC

–

–

–

–

++

SOC

–

–

–

–

++

  1. The absence or presence of labeling was indicated by (−) and (+), respectively. The extent of labeling was indicated with the number of (+). Results showed that with the reduced toxicity and extended animal survival, more connected downstream networks were labeled by the Mutant-VSV compared with the WT-VSV