Fig. 5
From: Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus
Selective deletion of DCC from CA3 pyramidal neurons impairs evoked synaptic transmission at Schaffer collateral synapses. a Representative traces of synaptic responses in CA1 pyramidal neurons in response to Schaffer collateral stimulation from control wild-type littermates (top, black) and R4ag11-Cre/DCCfl/fl (CA1 cKO; bottom, red). b-c Group data show evoked EPSC amplitude in CA1 pyramidal neurons in response to incremental stimulation intensity of Schaffer collaterals (b; F8,192 = 0.18, p = 0.993) and paired-pulse ratio across a range of interstimulus intervals (c; ISI; Interaction: F6,78 = 0.76, p = 0.602) in R4ag11-Cre/DCCfl/fl (CA1 cKO, red) and control littermates (black). d-f Representative traces (d) and group data (e; Interaction: F8,112 = 3.13, p = 0.003) from CA1 pyramidal neurons in control wild-type littermates (top, black) and Grik4-Cre/DCCfl/fl (CA3 cKO; bottom, green) in response to incremental stimulation intensity of Schaffer collaterals. f Group data also show paired-pulse ratio across a range of ISI (Interaction: F6,84 = 0.53, p = 0.780). ** denotes p < 0.01