Fig. 5
From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
Summary of differentially expressed genes resulting from RNA-seq comparisons of RML-infected PLX5622-treated mice at 80 dpi,100 dpi, and clinical endpoint (~ 127 dpi) relative to RML-infected Untreated mice at 80 dpi, 100 dpi, and clinical endpoint (~ 157 dpi). In panel a, the red indicates the proportion of genes increased in the brains of PLX5622-treated mice, while blue represents the proportion of genes decreased in the brains of PLX5622-treated mice. Panel b indicates the number of differentially expressed genes either increased (red bars) or decreased (blue bars) that are predominately expressed in the indicated cells of the CNS during basal conditions. MG refers to microglia, Oligo refers to oligodendrocytes, N refers to neurons, and A refers to astrocytes. Genes that are similarly expressed in more than one cell type are not shown for simplicity. The specific genes, their fold change, their cellular expression, and statistical analysis can be found in Additional File, Supplementary Dataset 5