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Table 2 Top thirty genes predominantly expressed by microglia that are increased in the brains of prion-infected mice

From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

Gene Description 80 dpia 100 dpi ~ 157 dpi
FCb P value FC P value FC P value
Lag3c lymphocyte-activation gene 3 2.1 9.7 × 10− 4 4.5 1.2 × 10− 6 8.3 1.5 × 10−9
Cst7 cystatin F 1.5 2.8 × 10− 2 3.8 1.5 × 10− 5 20.8 1.5 × 10− 11
Clec7ac C-type lectin domain family 7, member a 1.6 4.7 × 10− 2 2.9 2.6 × 10− 4 7.9 2.7 × 10− 6
Itgaxc integrin alpha X/CD11c 1.4 6.1 × 10− 3 2.8 1.5 × 10−6 9.4 5.1 × 10− 12
C1qb complement component 1q, beta 1.2 4.6 × 10− 1 2.7 7.8 × 10− 3 4.6 1.5 × 10− 5
H2-D1 histocompatibility 2, D region locus 1 1.3 2.5 × 10− 2 2.3 8.3 × 10− 5 3.5 9.8 × 10− 8
H2-K1 histocompatibility 2, K1, K region 1.4 1.2 × 10− 1 2.3 2.2 × 10− 4 3.5 2.3 × 10− 6
B2m beta-2 microglobulin 1.2 4.6 × 10− 1 2.2 9.7 × 10− 4 3.7 1.9 × 10− 6
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 1.7 3.2 × 10− 2 2.2 4.3 × 10− 4 4.7 1.2 × 10− 5
Fcgr4 Fc receptor, IgG, low affinity IV 1.4 3.8 × 10− 3 2.2 1.3 × 10− 5 3.4 1.4 × 10− 7
Trem2 triggering receptor expressed on myeloid cells 2 1.3 4.5 × 10− 2 2.2 3.6 × 10− 4 5.7 3.9 × 10− 9
C1qa complement component 1 q alpha 1.2 2.7 × 10− 1 2.2 1.1 × 10− 3 5.6 9.5 × 10− 6
Fcrlsd Fc receptor-like S, scavenger receptor 1.1 4.9 × 10− 1 2.2 2.5 × 10− 4 4.9 5.4 × 10− 9
Bst2 bone marrow stromal cell antigen 2 1.5 5.4 × 10− 2 2.1 3.8 × 10− 4 3.6 1.1 × 10− 5
Cd52 CD52 antigen 1.5 2.1 × 10− 1 2.1 4.9 × 10− 2 3.4 1.1 × 10− 2
Ly86 lymphocyte antigen 86 1.3 1.2 × 10− 1 2.1 4.0 × 10− 4 3.7 1.6 × 10− 7
Gpnmbc glycoprotein (transmembrane) nmb 1.1 3.9 × 10− 1 1.5 4.1 × 10− 4 13.6 1.1 × 10− 11
Lyz2 lysozyme 2 0.9 6.0 × 10− 1 1.6 2.0 × 10− 2 11.8 2.0 × 10− 9
C1qc complement component 1 q C chain 0.7 5.6 × 10− 1 1.1 7.7 × 10− 1 5.8 2.8 × 10− 3
Lcn2 lipocalin 2 1.0 7.1 × 10− 1 1.2 1.8 × 10− 1 4.9 6.9 × 10− 9
Ctss cathepsin S 1.2 4.0 × 10− 1 1.8 1.9 × 10− 3 4.8 8.5 × 10− 8
Itgb2 integrin beta 2 1.1 1.3 × 10− 1 1.8 5.5 × 10− 5 4.6 4.3 × 10− 11
Fcgr2b Fc receptor, IgG, low affinity Iib 1.1 3.6 × 10− 1 1.8 3.4 × 10− 4 4.5 9.1 × 10− 9
Fcgr2b Fc receptor, IgG, low affinity Iib splicing variant 1.2 1.7 × 10− 1 1.8 1.5 × 10− 4 4.5 4.0 × 10− 9
Fcer1g Fc receptor, IgE, high affinity I, gamma 1.2 3.7 × 10− 1 1.9 3.4 × 10− 3 4.4 3.8 × 10− 7
Ly9 lymphocyte antigen 9 1.1 1.9 × 10− 1 1.7 7.7 × 10− 4 4.3 3.7 × 10− 9
Tyrobp TYRO protein tyrosine kinase binding protein 1.3 1.5 × 10− 1 1.7 7.8 × 10− 3 4.3 1.3 × 10− 7
C3 complement component 3 0.9 4.2 × 10− 1 1.2 3.3 × 10− 2 4.2 2.2 × 10− 9
Cyba cytochrome b-245, alpha polypeptide 1.1 4.8 × 10− 1 1.8 4.0 × 10− 3 4.2 1.3 × 10− 7
Ccl3 chemokine (C-C motif) ligand 3 1.2 1.9 × 10− 1 1.9 4.8 × 10− 4 4.1 6.7 × 10− 9
  1. Bolded values denote genes increased ≥2.0-fold with p values ≤0.05 (5.0 × 10− 2) in RML-infected mice
  2. Values in italics are increased between 1.5-fold and 1.9-fold with p values ≤0.05 (5.0 × 10− 2) in RML-infected mice
  3. adpi days post inoculation
  4. bFC fold change
  5. c Genes that are also increased in the MGnD phenotype
  6. d Gene that is decreased in the MGnD phenotype but increased during prion disease