Table 2 Top thirty genes predominantly expressed by microglia that are increased in the brains of prion-infected mice
From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
Gene | Description | 80 dpia | 100 dpi | ~ 157 dpi | |||
|---|---|---|---|---|---|---|---|
FCb | P value | FC | P value | FC | P value | ||
Lag3c | lymphocyte-activation gene 3 | 2.1 | 9.7 × 10− 4 | 4.5 | 1.2 × 10− 6 | 8.3 | 1.5 × 10−9 |
Cst7 | cystatin F | 1.5 | 2.8 × 10− 2 | 3.8 | 1.5 × 10− 5 | 20.8 | 1.5 × 10− 11 |
Clec7ac | C-type lectin domain family 7, member a | 1.6 | 4.7 × 10− 2 | 2.9 | 2.6 × 10− 4 | 7.9 | 2.7 × 10− 6 |
Itgaxc | integrin alpha X/CD11c | 1.4 | 6.1 × 10− 3 | 2.8 | 1.5 × 10−6 | 9.4 | 5.1 × 10− 12 |
C1qb | complement component 1q, beta | 1.2 | 4.6 × 10− 1 | 2.7 | 7.8 × 10− 3 | 4.6 | 1.5 × 10− 5 |
H2-D1 | histocompatibility 2, D region locus 1 | 1.3 | 2.5 × 10− 2 | 2.3 | 8.3 × 10− 5 | 3.5 | 9.8 × 10− 8 |
H2-K1 | histocompatibility 2, K1, K region | 1.4 | 1.2 × 10− 1 | 2.3 | 2.2 × 10− 4 | 3.5 | 2.3 × 10− 6 |
B2m | beta-2 microglobulin | 1.2 | 4.6 × 10− 1 | 2.2 | 9.7 × 10− 4 | 3.7 | 1.9 × 10− 6 |
Lgals3bp | lectin, galactoside-binding, soluble, 3 binding protein | 1.7 | 3.2 × 10− 2 | 2.2 | 4.3 × 10− 4 | 4.7 | 1.2 × 10− 5 |
Fcgr4 | Fc receptor, IgG, low affinity IV | 1.4 | 3.8 × 10− 3 | 2.2 | 1.3 × 10− 5 | 3.4 | 1.4 × 10− 7 |
Trem2 | triggering receptor expressed on myeloid cells 2 | 1.3 | 4.5 × 10− 2 | 2.2 | 3.6 × 10− 4 | 5.7 | 3.9 × 10− 9 |
C1qa | complement component 1 q alpha | 1.2 | 2.7 × 10− 1 | 2.2 | 1.1 × 10− 3 | 5.6 | 9.5 × 10− 6 |
Fcrlsd | Fc receptor-like S, scavenger receptor | 1.1 | 4.9 × 10− 1 | 2.2 | 2.5 × 10− 4 | 4.9 | 5.4 × 10− 9 |
Bst2 | bone marrow stromal cell antigen 2 | 1.5 | 5.4 × 10− 2 | 2.1 | 3.8 × 10− 4 | 3.6 | 1.1 × 10− 5 |
Cd52 | CD52 antigen | 1.5 | 2.1 × 10− 1 | 2.1 | 4.9 × 10− 2 | 3.4 | 1.1 × 10− 2 |
Ly86 | lymphocyte antigen 86 | 1.3 | 1.2 × 10− 1 | 2.1 | 4.0 × 10− 4 | 3.7 | 1.6 × 10− 7 |
Gpnmbc | glycoprotein (transmembrane) nmb | 1.1 | 3.9 × 10− 1 | 1.5 | 4.1 × 10− 4 | 13.6 | 1.1 × 10− 11 |
Lyz2 | lysozyme 2 | 0.9 | 6.0 × 10− 1 | 1.6 | 2.0 × 10− 2 | 11.8 | 2.0 × 10− 9 |
C1qc | complement component 1 q C chain | 0.7 | 5.6 × 10− 1 | 1.1 | 7.7 × 10− 1 | 5.8 | 2.8 × 10− 3 |
Lcn2 | lipocalin 2 | 1.0 | 7.1 × 10− 1 | 1.2 | 1.8 × 10− 1 | 4.9 | 6.9 × 10− 9 |
Ctss | cathepsin S | 1.2 | 4.0 × 10− 1 | 1.8 | 1.9 × 10− 3 | 4.8 | 8.5 × 10− 8 |
Itgb2 | integrin beta 2 | 1.1 | 1.3 × 10− 1 | 1.8 | 5.5 × 10− 5 | 4.6 | 4.3 × 10− 11 |
Fcgr2b | Fc receptor, IgG, low affinity Iib | 1.1 | 3.6 × 10− 1 | 1.8 | 3.4 × 10− 4 | 4.5 | 9.1 × 10− 9 |
Fcgr2b | Fc receptor, IgG, low affinity Iib splicing variant | 1.2 | 1.7 × 10− 1 | 1.8 | 1.5 × 10− 4 | 4.5 | 4.0 × 10− 9 |
Fcer1g | Fc receptor, IgE, high affinity I, gamma | 1.2 | 3.7 × 10− 1 | 1.9 | 3.4 × 10− 3 | 4.4 | 3.8 × 10− 7 |
Ly9 | lymphocyte antigen 9 | 1.1 | 1.9 × 10− 1 | 1.7 | 7.7 × 10− 4 | 4.3 | 3.7 × 10− 9 |
Tyrobp | TYRO protein tyrosine kinase binding protein | 1.3 | 1.5 × 10− 1 | 1.7 | 7.8 × 10− 3 | 4.3 | 1.3 × 10− 7 |
C3 | complement component 3 | 0.9 | 4.2 × 10− 1 | 1.2 | 3.3 × 10− 2 | 4.2 | 2.2 × 10− 9 |
Cyba | cytochrome b-245, alpha polypeptide | 1.1 | 4.8 × 10− 1 | 1.8 | 4.0 × 10− 3 | 4.2 | 1.3 × 10− 7 |
Ccl3 | chemokine (C-C motif) ligand 3 | 1.2 | 1.9 × 10− 1 | 1.9 | 4.8 × 10− 4 | 4.1 | 6.7 × 10− 9 |