Fig. 1

IP6K1-KO mice show schizophrenia-like behavior and impaired hippocampus-dependent short-term memory but normal in long-term memory. a Significant decrease in PPI of acoustic startle in IP6K1 KO mice compared to IP6K1 WT littermate controls around all levels of prepulse (WT: n = 7; KO: n = 6; two-way ANOVA; main effect of genotype, F_(1,55) = 11.03, **P < 0.01; main effect of prepulse level, F_(4,55) = 18.79, P < 0.0001;no significant interaction). b No change in Spontaneous Y maze at alteration rate in IP6K1 KO mice versus IP6K1 WT littermate controls(WT: n = 6; KO: n = 8; two tailed student t-test; ns: no significant; P ≥ 0.05). c Freezing levels of IP6K1 WT and IP6K1 KO mice before (pretraining) and 1 h after (retrieval) contextual fear shock. IP6K1 KO mice exhibited significantly decreased freezing levels during retrieval test versus IP6K1 WT (WT: n = 13; KO: n = 14; two-way ANOVA; main effect of genotype, F_(1,50) = 4.04, *P < 0.05; main effect of condition, F_(1,50) = 68.45, P < 0.0001; Bonferroni posttests, *P < 0.05). d Freezing levels of IP6K1 WT and IP6K1 KO mice before (pretraining) and 24 h after (retrieval) contextual fear conditioning. IP6K1 KO mice show no significant freezing level change compared to IP6K1 WT mice (WT: n = 7; KO: n = 6; two-way ANOVA; main effect of genotype, F_(1,22) = 0.05, P ≥ 0.05; main effect of condition F_(1,22) = 44.84, P < 0.0001; Bonferroni posttest, ns: not significant). e Hippocampal LTP is occurred on IP6K1 KO (WT: n = 5; paired t-test; potentiation, 1.15 ± 0.14, P ≥ 0.05; KO: n = 6; paired t-test; potentiation, 1.30 ± 0.07, *P < 0.05), but not significantly difference on magnitude of LTP. (paired t-test; P ≥ 0.05; ns: no significant). f LFS-induced hippocampal LTD is occurred both IP6K1 WT and IP6K1 KO (WT: n = 7; paired t-test; depression: 0.60 ± 0.05; ***P < 0.001; KO: n = 7; paired t-test; depression, 0.69 ± 0.02, **P < 0.01). Magnitude of LTD were no significant change between IP6K1 WT and IP6K1 KO. (paired t-test; P ≥ 0.05; ns: no significant)