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Fig. 6 | Molecular Brain

Fig. 6

From: 1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Fig. 6

1-O-acetylgeopyxin A reduces gp120-induced mechanical allodynia. a Paw withdrawal threshold of adult male rats (n = 4-6) was measured 15 days after three intrathecal injections of gp120. Rats were treated with (intrathecally (i.th.) via catheter) saline (vehicle) or 1-O-acetylgeopyxin A (2 μg/5 μL) as indicated. Asterisks indicate statistical significance compared with saline treatment (*p < 0.05; two-way ANOVA with a Student− Neuman−Kuels post hoc test). b Area under the curve was derived as indicated above using GraphPad Prism. Statistical significance is indicated by asterisks (*p < 0.05, Mann−Whitney test) in comparison to vehicle-treated rats. Experimenter was blinded to the treatment condition.

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Molecular Brain

ISSN: 1756-6606