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Table 1 Effects of 1-O-acetylgeopyxin A on gating properties of Voltage-Gated Channels in DRG Neuronsa

From: 1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Calcium Total
  DMSO 1-O-acetylgeopyxin A (20 μM)
Activation
V1/2 (P = 0.0188) −3.9 ± 0.8 (21) −6. 7± 0.8 (21)*b
(P = 0.1966) 7.1 ± 0.7 (21) 8.4 ± 0.7 (21)
Inactivation
V1/2 (P = 0.0363) −26.8 ± 0.8 (19) −24.0 ± 1.0 (20)*b
(P = 0.8775) −12.8 ± 0.8 (19) −12.6 ± 1.0 (20)
Sodium
  DMSO 1-O-Acetylgeopyxin A (20 μM)
Activation
V1/2 (P = 0.0001) −20.1 ± 0.7 (16) −14.9 ± 0.8 (19)*b
(P = 0.0013) 4.4 ± 0.6 (16) 7.7 ± 0.7 (19)*b
Inactivation
V1/2 (P = 0.0006) −47.4 ± 1.0 (15) −40.6 ± 1.4 (18)*b
(P = 0.1244) −10.9 ± 0.9 (15) −13.5 ± 1.3 (18)
  1. aValues are means±SEM calculated from fits of the data from the indicated number of individual cells to the Boltzmann equation; V1/2 midpoint potential (mV) for voltage-dependent activation or inactivation; k, slope factor. bSignificantly different from the value for DMSO (*P < 0.05; Student’s t test)