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Table 1 Effects of 1-O-acetylgeopyxin A on gating properties of Voltage-Gated Channels in DRG Neuronsa

From: 1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Calcium Total

 

DMSO

1-O-acetylgeopyxin A (20 μM)

Activation

V1/2 (P = 0.0188)

−3.9 ± 0.8 (21)

−6. 7± 0.8 (21)*b

k (P = 0.1966)

7.1 ± 0.7 (21)

8.4 ± 0.7 (21)

Inactivation

V1/2 (P = 0.0363)

−26.8 ± 0.8 (19)

−24.0 ± 1.0 (20)*b

k (P = 0.8775)

−12.8 ± 0.8 (19)

−12.6 ± 1.0 (20)

Sodium

 

DMSO

1-O-Acetylgeopyxin A (20 μM)

Activation

V1/2 (P = 0.0001)

−20.1 ± 0.7 (16)

−14.9 ± 0.8 (19)*b

k (P = 0.0013)

4.4 ± 0.6 (16)

7.7 ± 0.7 (19)*b

Inactivation

V1/2 (P = 0.0006)

−47.4 ± 1.0 (15)

−40.6 ± 1.4 (18)*b

k (P = 0.1244)

−10.9 ± 0.9 (15)

−13.5 ± 1.3 (18)

  1. aValues are means±SEM calculated from fits of the data from the indicated number of individual cells to the Boltzmann equation; V1/2 midpoint potential (mV) for voltage-dependent activation or inactivation; k, slope factor. bSignificantly different from the value for DMSO (*P < 0.05; Student’s t test)
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Molecular Brain

ISSN: 1756-6606