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Fig. 3 | Molecular Brain

Fig. 3

From: Characterization of a pathogenic variant in GBA for Parkinson’s disease with mild cognitive impairment patients

Fig. 3

The rs12411216 SNP mutation decreased the binding activity of transcription factor E2F4. WT labelled probe: wild-type SNP biotin-labelled probe; T-SNP labelled probe: mutant SNP biotin-labelled probe; Competitors: a large number of biotin-free markers. The EMSA demonstrated that the WT probe, T-SNP probe, complexes of probes and E2F4 antibody could bind to the nuclear extract. The rs12411216 mutation decreased the binding ability of transcription factor E2F4

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Molecular Brain

ISSN: 1756-6606