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Fig. 7 | Molecular Brain

Fig. 7

From: Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum

Fig. 7

Region-specific blood vessel formation and locations of perivascular cells in the injured brain. a Sections obtained from the intact and ATP-injected cortex and striatum at the indicated times were immunostained for CD31 to label blood vessels. Arrowheads, vessels located along the meninges in the intact cortex; arrows, vessels in the parenchyma in intact and injured brains. b Colocalization of CD31 and Col1a1. Sections from intact and ATP-injected brains were double-labeled with antibodies for CD31 and Col1a1 (perivascular fibroblasts), and visualized using Alexa 488- and 594-conjugated secondary antibodies. CD31 and Col1a1 were colocalized in the intact and injured cortex and striatum (arrows). Dotted lines, edges of the damage areas. c Sections were double-labeled with antibodies for GFAP and CoL1A1. Arrows, astrocytes near blood vessels and/or in vessel-rich regions; arrowheads, astrocytes in vessel-rare regions. Relative intensities of GFAP and CoL1A1 in the regions of interest (white boxes) were plotted

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Molecular Brain

ISSN: 1756-6606