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Fig. 2 | Molecular Brain

Fig. 2

From: Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth

Fig. 2

The level of activated pSTAT3 stimulated by leptin decreased in the ARH-A and ARH-C of Shh-cKO mice compared with control littermates. a Experimental scheme. Shh-cKO mice or control littermates at P35 received a single i.p. injection of leptin and were sacrificed after 1 h. b Schematic diagrams depicting the indicated brain regions for analysis. c-h Representative images showing leptin-activated pSTAT3 and NeuN expression in the indicated subregions of the hypothalamus of Shh-cKO mice and control littermates. Scale bars, 100 μm. I Quantification of the ratio of pSTAT3 + NeuN+ cells to total NeuN+ cells (n = 4 mice for each genotype). ***p < 0.001; Student’s two-tailed, unpaired t-test. Error bars indicate s.e.m.

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Molecular Brain

ISSN: 1756-6606