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Fig. 5 | Molecular Brain

Fig. 5

From: Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth

Fig. 5

Depletion of Lepr in nestin-expressing cells enhances the differentiation of these cells towards the neuronal and oligodendroglia fates but inhibits the astrocyte fate early in postnatal development a Experimental scheme. Nes-cKO mice or control littermates received BrdU twice daily between P7 and P15 and were sacrificed at P35. b-d Representative images showing BrdU-expressing cells colocalizing with NeuN (b), OLIG2 (c) or GFAP (d) by immunostaining of samples from control or Nes-cKO mice. Shown to the right is the quantification of the percentage of the BrdU+ cells displaying co-localization with NeuN, OLIG2 or GFAP (n = 4 mice per group), Scale bars, 100 μm. *p < 0.05, **p < 0.01, ***p < 0.001; Student’s two-tailed, unpaired t-test. Error bars indicate s.e.m.

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Molecular Brain

ISSN: 1756-6606