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Fig. 2 | Molecular Brain

Fig. 2

From: Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson’s disease

Fig. 2

Membrane depolarization induced by increasing extracellular K+ and blocking GABAA receptors in differentiated SH-SY5Y cells. a Representative responses (∆F/F) of Fast voltage-sensitive dye imaging of Di-4-ANEPPS-loaded SH-SY5Y cells before, during, and after 10 mM KCL. Scale bar, 100 μm. b Immunofluorescent staining of GABAA α1(green) and DAPI (blue) in the differentiated SH-SY5Y cells. Scale bar: 200 μm. c Representative responses of Fast voltage-sensitive dye imaging of Di-4-ANEPPS-loaded SH-SY5Y cells before, during, and after 100 μM Picrotoxin. Scale bar, 100 μm

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