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Fig. 1 | Molecular Brain

Fig. 1

From: Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

Fig. 1

Genes encoding proteins regulating energy metabolism are differentially expressed in FTD3 versus control neurons derived from patient-specific iPSCs. a Immunocytochemistry of hiPSC-derived neurons for MAP 2, TAU, CTIP2, vGLUT1 and TUJ1. Scale bar, 50 μm for all. b Schematic of tandem mass tag (TMT) protein labelling of hiPSC-derived neurons for mass spectrometry-based quantitative analyses. c Key metabolism-relevant genes and metabolites involved in energy metabolic pathways including glycolysis and oxidative metabolism. Heatmaps for gene expression changes determined at both mRNA and protein levels, including genes encoding proteins responsible for glycolysis, the tricarboxylic acid (TCA) cycle, the mitochondrial electron transport chain and glucose and amino acid transportation. mRNA expression data were extracted from previously-published RNA-seq data. Fold-changes are represented by Log2 ratio for FTD3 neurons versus isogenic controls

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Molecular Brain

ISSN: 1756-6606