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Fig. 6 | Molecular Brain

Fig. 6

From: Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model

Fig. 6

Overexpression of Slit2 improves paravascular clearance in the peri-infarct area. a Representative xyz overlaid images of the cortical vascular (Rhodamine B: red color) and paravascular spaces (FITC-dextran: green color) in the peri-infarct area at 5, 15, 30, 45, and 60 min after FITC-dextran injection (25 × objective). b Linear analysis of the FITC-dextran fluorescence emission intensity in the paravascular space. c Histograms of FITC-dextran fluorescence intensity in the paravascular space at 5 and 60 min after cisterna magna injection among WT sham, WT MI, Slit2-Tg sham, and Slit2-Tg MI groups. d Immunofluorescence staining of AQP4 and the astrocyte marker GFAP (25 × objective, magnified by 3). e Comparison of GFAP+ astrocyte numbers and AQP4 polarity among WT sham, WT MI, Slit2-Tg sham, and Slit2-Tg MI groups. Each dataset is expressed as mean ± SD. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. n = 6 mice

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Molecular Brain

ISSN: 1756-6606