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Fig. 5 | Molecular Brain

Fig. 5

From: Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease

Fig. 5

Gene set enrichment analysis. Figure 5 depicts the significantly altered KEGG and HALLMARK gene sets in the null/+, EOfAD-like/+ and transheterozygous mutant brains relative their wild type siblings. The sizes of the dots indicate the negative log10 of the harmonic mean p-value (i.e. larger dots indicate greater statistical significance) of three methods of enrichment analysis (fry, camera and fgsea) when combined within each comparison. Gene sets are grouped as to the comparisons in which they are significant. Numbers associated with each dot are FDR adjusted harmonic mean p-values.

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Molecular Brain

ISSN: 1756-6606