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Fig. 7 | Molecular Brain

Fig. 7

From: Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease

Fig. 7

Loss of wild type sorl1 results in dysregulation of genes with an iron responsive element in their transcript’s 3′ untranslated region, and of genes involved in the cellular response to hypoxia. The harmonic mean p-values for the enrichment analyses of gene sets with a, iron responsive elements (IRE) in their untranslated regions, and b, regulated by the HIF1 transcription factor, are shown with the significant gene sets in blue. The logFCs of genes in brains of each genotype with c, a canonical IRE in their transcript’s 3′ untranslated region and d, shown to be downregulated by loss of HIF1 activity. The genes and comparisons are clustered based on their Euclidian distance

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Molecular Brain

ISSN: 1756-6606