Fig. 1

Genetic deletion of Hv1 results in better locomotor recovery after SCI. a Schematic showing injury site and regions investigated for white matter sparing in this study. b Total BMS scores in WT and Hv1^−/− mice measured at different time points following SCI and sham controls (WT, n = 11; Hv1^−/−, n = 18). Hv1^−/− mice show significantly improved locomotor recovering from day 2 (*P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA with repeated measures). c Representative images of perfused spinal cord from WT and Hv1^−/− mice from sham, 1 d, 3 d and 7 d after SCI (Scale: 5 mm). d Bar graph denotes the percentage of white matter area out of total spinal cord section area, represented as mean ± SEM. e Representative images of H&E stained spinal cord sections at different locations from the epicenter of injury obtained from WT and Hv1^−/− mice at 7 d after SCI. (WT, n = 4; Hv1^−/−, n = 6; *P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA