Neuronal activity regulates alternative exon usage

Table 2 Genes with significant activity-dependent exon usage identified through FIRMA

Gene name	Probeset ID	Probeset number	Exon number	F^s score^a	F⁰ score^b	FDR^c	DE^d
Rcan1	4567413	4	3	444.6	0.345	0.0	−
Dclk1	5144145	10	9	96.8	0.525	0.0	−
Mt1	5480425	1	2	70.9	0.621	0.0	+
Vmp1	4780502	11	13	50.1	0.542	0.0	−
Ntf3	5239597	7	3	14.8	0.371	0.067	+
Rheb	5489435	8	8	15.1	0.404	0.071	+
Grik2	5235346	9	8	15.5	121.96	0.077	+
Car2	4363942	22	13	16.1	0.347	0.083	−
Homer1	5397705	6	2	161.6	0.581	0.091	+
Nav2	4655500	3	9	169.6	0.841	0.1	−

FIRMA (F) scores represent the discrepancy of one probeset from the other probesets in the same gene and were calculated for every probeset and sample
Italics indicates genes also found highly significantly spliced using time-dependent ANOSVA (Table 1)
^aF^s score, corresponds to samples collected after seizure compared to controls and samples
^bF⁰ score, corresponds to samples collected after vehicle treatment compared to controls
^cFDR, False discovery rate calculated from F scores for the alternative and the null model
^dDE, differentially expressed, indicates whether the whole gene was identified as induced by neuronal activity in our initial analysis (Table S1)

ISSN: 1756-6606