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Table 1 Summary of significant differences in behavioral tests in App-KI mice in this study vs. previous studies

From: Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease

Behavioral tests Test significance Significant difference References
Y-maze Short-term memory Yes (6 months) Saito et al. [13]
Place preference and reversal task Spatial learning and reversal learning Yes (13–14 months) Masuda et al. [16]
Serial reaction time task Impulsivity and attention Yes (13–14 months)  
Place avoidance Extinction learning Yes (8–9 months)  
Delay discounting task Compulsive behavior Yes (8–9 months)  
Novel object recognition Recognition memory Not detected (6 months) Whyte et al. [17]
Y-maze Working memory Not detected (6 months)  
Morris water maze Spatial reference memory Not detected (6 months)  
Open field Anxiety Yes (6 months)  
Fear conditioning Fear learning Not detected (15–18 months) Sakakibara et al. [14]
Elevated plus maze Anxiety-related behavior Yes (6–18 months)  
Barnes maze Spatial memory Yes (8 months)  
Spatial reversal learning Flexibility and impulse control Not detected (8 months)  
Morris water maze Spatial reference memory Not detected (10–11 months) Latif-Hernandez et al. [15]
Cage activity and exploration Spontaneous activity Yes (3 and 10 months)  
Social Preference Social Novelty (SPSN) test Social memory Not detected (3, 6, and 10 months)  
Location discrimination Pattern separation Yes (4–5 months) Present study
Different object–location paired-associate learning Paired-associative memory Yes (4–6 months)  
Visual discrimination, Reversal learning Cognitive flexibility Not detected (4–5 months)  
Morris water maze Spatial reference memory Not detected (6 months)  
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