Fig. 5

Sociability and social-novelty preference of protrudin-deficient mice. a, b Time spent in the chamber with an empty cage, the center chamber, and the chamber with a cage containing a stranger mouse (stranger 1) (a) as well as time spent around each cage (b) in the three-chamber sociability test. c, d Time spent in the chamber with the cage containing stranger 1, the center chamber, and the chamber with the cage now containing a novel unfamiliar mouse (stranger 2) (c) as well as time spent around each cage (d) in the three-chamber test of social-novelty preference. All data are means + SEM (WT mice, n = 22; PRT^–/– mice, n = 17). P values for differences between genotypes were determined with Student's t test (a–c) or Welch t test (d). The results of all statistical analysis are provided in Additional file 1: Table S1