Fig. 5
From: MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus
Analysis of genes that underwent differential alternative splicing events in baseline and in learning state upon MeCP2 knock-down. a, b Schematic representation of comparisons used (top). Gene ontology (GO) analysis for genes that underwent differential alternative splicing in the dorsal hippocampi MeCP2-shRNA mice in baseline (a) and learning state (b) conditions. Enriched GO terms (Fisher’s exact test P < 0.001) for genes that underwent inclusion or exclusion (q-value < 0.05) events. The blue and red bars represent − log10 (P-value) of the GO enrichment for inclusion and exclusion events, respectively. The vertical dashed line serves as a marker for P-value = 0.001 [− log10 (P-value) = 3]. Absence of a colored bar means that genes of that GO term were not enriched in that specific category. ΔPSI: delta “percent spliced in”. c Venn diagram showing overlap between total number of differentially expressed genes and genes that underwent differential alternative splicing events in learning-induced conditions in the adult dorsal hippocampus of control mice (control-shRNA). d Venn diagram showing overlap between total number of differentially expressed genes and genes that underwent differential alternative splicing events in learning-induced conditions when MeCP2 was knocked down in the adult dorsal hippocampus (MeCP2-shRNA)