Fig. 4
Oligodendrocyte lineage–specific Chd8 heterozygous mutant mice manifest altered functional brain connectivity. a Correlation (Fisher’s z-score) matrices derived from rsfMRI BOLD signal analysis for connections between brain regions related to ASD in Olig1-Cre/Chd8L+/F and Olig1-Cre/Chd8+/+ mice (n = 12 mice per genotype). PL prelimbic cortex, ILA infralimbic cortex, ORB orbitofrontal cortex, DG dentate gyrus, CA1 cornu ammonis 1, SUB subiculum, BLA basolateral amygdala, CP caudoputamen, ACB nucleus accumbens, VTA ventral tegmental area, PAG periaqueductal gray. b, Significant changes in the strength (absolute value of the correlation coefficient) of functional connectivity between the indicated brain regions of Olig1-Cre/Chd8L+/F versus Olig1-Cre/Chd8+/+ mice (n = 12 mice per genotype). The significantly altered connections (Student’s t test) in the mutant mice are represented by red (increased absolute correlation) or blue (decreased absolute correlation) lines in a brain depiction, although these differences did not survive multiple comparison correction. The results of rsfMRI processing without GSR are provided in Additional file 3: Fig. S3