Fig. 1

Ganglionic injection of RS504393 inhibits the mechanical and thermal hyperalgesia caused by intrathecal CCL2. a Prevention of CCL2 (100 ng, i.t.)-induced mechanical hyperalgesia by RS504393 (1 μg, 20 μg, intervertebral foramen injection (i.f.)). b Reversal of CCL2-induced heat hyperalgesia by RS504393 (1 μg, 20 μg, i.f.). c, d Basal mechanical threshold (c) and thermal latency (d) was not altered by RS504393 (20–80 μg, i.f). *and^#and⁺P < 0.05, **and^##P < 0.01, ***and^###and⁺⁺⁺P < 0.001. Two-Way ANOVA followed by post-hoc Bonferroni test (n = 10–11 mice/group). Data are expressed as mean ± SEM