Fig. 1

The 24-h-restraint stress increased SIRT1 activity in hippocampus. a 24-h-restraint mice were subjected to acute restraint for 24 h and used for behavioral or biochemical experiments 5 weeks later. b Decreased the long-term depressive-like behaviors of SPT (n = 7 per group), *p < 0.05. c Increased immobility time in restraint mice in the forced swimming test (n = 11 per group); *p < 0.05. d No difference in levels of SIRT1 (n = 4 per group). e Levels of SIRT1 mRNA in the hippocampus (n = 4 per group). f Increased SIRT1 activity in restraint group than that in control group (n = 4 per group); **p < 0.01. g The duration of immobility time in forced swim test was no significant change in the conditional Sirt1 KO mice after 24-h-restraint stress (n = 8 per group). Data are presented as mean ± SEM. Ctrl control, Res restraint, n.s. no significance