Fig. 2
From: Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice
Nicotinamide could rescue the depressive-like behaviors induced by 24-h restraint. a NAM was administered 2 days after the restraint for the previous 5 weeks. b Sucrose consumption of three groups in the sucrose preference test (n = 10/9/9 per group); *p < 0.05. c Immobility time in the forced swim test (n = 14/13/13 per group); *p < 0.05. d, e Levels of SIRT1 protein and mRNA in the hippocampus (n = 4 per group). f The change of SIRT1 activity in the hippocampus of mice by NAM treatment (n = 4 per group); *p < 0.05, **p < 0.01. g The relative of ATP level in the hippocampus of mice (n = 6/6/7 per group); *p < 0.05, **p < 0.01