Fig. 3
From: Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice
Sirt1flox/flox; Nestin-Cre mice exhibited antidepressant behaviors with increased ATP in the hippocampus. a Western blot was used to detect SIRT1 expression. b Immobility time in the forced swim test of different groups (n = 7/12/5 per group); *p < 0.05, **p < 0.01. c The relative of ATP level in the hippocampus (n = 4 per group); **p < 0.01. d Schematic representation of key molecules in the restraint model and Sirt1flox/flox; Nestin-Cre mice