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Fig. 5 | Molecular Brain

Fig. 5

From: Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice

Fig. 5

Behavioral consequences of GAD67 knockdown in mice. a, b Body weights and latency to fall from a cylinder in the rotarod test for Dox-treated Gad1+/+ and Gad1tTA/STOP−tetO mice. c Examples of the path traveled in the open-field test by two Gad1+/+ and two Gad1tTA/STOP−tetO mice treated with Dox. d Acoustic startle responses of Dox-treated Gad1+/+ and Gad1tTA/STOP−tetO mice. Startle amplitudes by the sounds indicate the startle responses (A.U.). *p < 0.05 and ***p < 0.001 between genotypes (simple main effect of two-way ANOVA). e PPI responses of Dox-treated Gad1+/+ and Gad1tTA/STOP−tetO mice. PPI was defined as the percent decline in the startle response (% Inhibition)

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