Fig. 1
From: Core transcriptional regulatory circuits in prion diseases
Early and late alterations of cellular processes associated with prion diseases along disease progression. A-C) Three major differential expression patterns shared in B6-RML, FVB-RML, and Prnp0/+ − RML along disease progression. These patterns included 107 early up-regulated (EU; A), 502 late up-regulated (LU; B), and 274 down-regulated genes (DN; C). Gene expression changes were shown as log2-fold-changes between prion-infected and control brains at individual time points. Red and green colors indicate up- and down-regulation (positive and negative log2-fold-changes; see the color bar), respectively. D) Gene ontology biological processes (GOBPs) enriched by the genes in each expression pattern. The color bar indicates the gradient of the enrichment p-value obtained from the DAVID software. Different colors were used to distinguish the enrichment for EU (orange), LU (magenta), and DN patterns (green). GOBPs were categorized into four (Groups 1 to 4) based on the enrichment patterns in the EU, LU, and DN gene clusters