Fig. 8
From: Scopoletin ameliorates anxiety-like behaviors in complete Freund’s adjuvant-induced mouse model
SP alleviated CFA-induced anxiety behaviors by activating the GABAA receptor. a Representative traces of locomotor activity in the OFT. b, c SP (50 mg/kg) administration effectively reversed the reduction in the time spent (b) and distance traveled (c) in the central area in the OFT, while this effect was reduced by co-administration of flumazenil (FLU, 10 mg/kg). d, e Mice showed a significant increase in the percentage of time spent in (d) and number of entries into (e) the open arms in the EPM test after SP (50 mg/kg) treatment, while this effect of SP was also reduced in the presence of FLU (10 mg/kg). n = 12 mice per group; **p < 0.01 versus control group; #p < 0.05, ##p < 0.01 versus vehicle group; &p < 0.05, &&p < 0.01 versus SP group