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Table 1 Differentially expressed proteins after TBI by iTRAQ

From: iTRAQ-based proteomic profiling reveals protein alterations after traumatic brain injury and supports thyroxine as a potential treatment

Accession

Description

Coverage (%)

MW (kDa)

Average

p-value

FC

Sham

TBI

D3ZVU4

Ribokinase (Rbks)

11

34

121.2

78.8

0.00070

0.65

P30337

N-chimaerin (Chn1)

4

38.2

120.4

79.7

0.0057

0.66

B1PLB1

CD34 antigen (Cd34)

11

41.2

115.1

84.9

0.00030

0.74

Q6XFR6

Glycophorin-C (Gypc)

27

10.4

113.0

87.0

0.0014

0.77

P08050

Gap junction alpha-1 protein (Gja1)

17

43

113.0

87.0

0.00010

0.77

P15384

Potassium voltage-gated channel subfamily A member 3 (Kcna3)

8

58.4

111.3

88.7

0.042

0.80

P49655

ATP-sensitive inward rectifier potassium channel 10 (Kcnj10)

4

42.5

111.1

88.9

0.012

0.80

Q6P7A9

Lysosomal alpha-glucosidase (Gaa)

4

106.1

110.9

89.0

0.00080

0.80

D3Z900

Mitochondrial amidoxime reducing component 2 (Marc2)

16

38.2

110.6

89.4

< 0.0001

0.81

D4A871

Leiomodin 3 (Lmod3)

2

66

110.5

89.5

0.013

0.81

P06685

Sodium/potassium-transporting ATPase subunit alpha-1 (Atp1a1)

46

113

110.3

89.7

< 0.0001

0.81

D3ZSW9

RUN and FYVE domain-containing 2 (LOC100910755)

2

69.9

110.3

89.8

0.013

0.81

P29101

Synaptotagmin-2 (Syt2)

31

47.2

110.1

89.9

< 0.0001

0.82

P11730

Calcium/calmodulin-dependent protein kinase type II subunit gamma (Camk2g)

28

59

109.9

90.1

0.00020

0.82

B4F7C1

G protein-coupled receptor 37-like 1, isoform CRA_a (Gpr37l1)

2

52.8

109.8

90.2

0.0060

0.82

D4A617

Ectonucleoside triphosphate diphosphohydrolase 1 (LOC103689954)

3

52

109.8

90.2

0.0071

0.82

Q8VHX0

Voltage-dependent calcium channel gamma-3 subunit (Cacng3)

10

35.5

109.6

90.4

0.0093

0.82

P06686

Sodium/potassium-transporting ATPase subunit alpha-2 (Atp1a2)

45

112.1

109.4

90.7

0.00010

0.83

A0A0G2K2B7

WD repeat domain 20 (Wdr20)

4

64.6

109.3

90.7

0.023

0.83

G3V8R5

Hormone-sensitive lipase (Lipe)

1

116.8

109.3

90.8

0.044

0.83

Q9Z2N6

Calcium/calmodulin-dependent protein kinase II inhibitor 2 (Camk2n2)

16

8.6

109.1

90.9

0.0095

0.83

P20760

Ig gamma-2A chain C region (Igg-2a)

16

35.2

90.8

109.3

0.022

1.20

Q9QYJ6

cAMP and cAMP-inhibited cGMP 3′,5′-cyclic phosphodiesterase 10A (Pde10a)

14

90.1

90.7

109.4

0.00040

1.21

D3ZMR1

Translocase of outer mitochondrial membrane 7 (Tomm7)

11

6.2

90.6

109.4

0.0010

1.21

P14173

Aromatic-l-amino-acid decarboxylase (Ddc)

11

54

90.6

109.4

0.0042

1.21

Q99P74

Ras-related protein Rab-27B (Rab27b)

5

24.6

90.6

109.4

0.0062

1.21

M0RDW3

N-acetyltransferase 8 (GCN5-related) family member 4 (LOC102556148)

3

25.6

90.4

109.6

0.0079

1.21

D3ZM03

Vacuolar ATPase assembly integral membrane protein VMA21 (LOC100912478)

12

11.4

90.3

109.8

0.0044

1.22

D3ZCC3

Slc24a4 protein (Slc24a4)

4

62.8

90.3

109.8

0.045

1.22

P14942

Glutathione S-transferase alpha-4 (Gsta4)

8

25.5

90.1

110.0

0.043

1.22

R9PXW6

RAS guanyl releasing protein 2, isoform CRA_b (Rasgrp2)

5

69.3

90.0

110.0

0.0025

1.22

F1LXF1

BCR, RhoGEF and GTPase-activating protein (Bcr)

6

120

90.0

110.0

0.0088

1.22

Q4QQT4

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (Ppp2r1b)

11

66

89.8

110.2

0.046

1.23

Q5FVI0

Arpp-21 protein (Arpp21)

34

9.6

89.8

110.2

0.00010

1.23

Q6JAM9

Transmembrane protein 35A (Tmem35a)

5

18.5

89.8

110.3

0.0054

1.23

D3ZEY4

Diacylglycerol kinase (Dgkq)

3

102.5

89.7

110.3

0.0078

1.23

A0A0G2JXN6

Galectin (Lgals3)

4

27.6

89.7

110.3

0.031

1.23

D4A1H2

Phosphatidylinositol-specific phospholipase C, X domain-containing 3 (Plcxd3)

8

36.3

89.5

110.5

0.021

1.23

F1LQY6

N-terminal EF-hand calcium-binding protein 2 (Necab2)

16

43.5

89.5

110.5

0.00020

1.23

F1LST1

Fibronectin (Fn1)

4

262.6

89.5

110.5

0.0024

1.24

D4A1J3

Paralemmin 3 (Palm3)

7

78.5

89.3

110.7

0.0020

1.24

Q5M971

Protein AF1q (Mllt11)

8

10

89.2

110.8

0.012

1.24

Q5M7T5

Serine (Or cysteine) peptidase inhibitor, clade C (Antithrombin), member 1 (Serpinc1)

16

52.2

89.1

110.9

< 0.0001

1.24

A0A0G2K896

Similar to RIKEN cDNA 1300017J02 (RGD1310507)

5

76.7

89.1

111.0

0.0014

1.25

P34926

Microtubule-associated protein 1A OS = Rattus norvegicus OX = 10,116 GN = Map1a PE = 1 SV = 1

32

299.3

89.0

111.1

0.00030

1.25

A0A0G2K728

Cadherin-4 (Cdh4)

3

94.4

89.0

111.1

0.035

1.25

P49805

Regulator of G-protein signaling 9 (Rgs9)

2

77.1

88.9

111.1

0.041

1.25

P22057

Prostaglandin-H2 d-isomerase (Ptgds)

9

21.3

88.8

111.2

0.011

1.25

Q8R490

Cadherin 13 (Cdh13)

13

78

88.7

111.3

0.00010

1.25

A0A0G2K613

Uncharacterized protein

22

19.8

88.7

111.3

< 0.0001

1.25

F1M7Z2

IQ and AAA domain-containing protein 1 (Iqca)

1

99.3

88.5

111.6

0.0043

1.26

Q7TSE9

HCLS1-associated protein X-1 (Hax1)

9

31.4

88.3

111.8

0.0070

1.27

Q6J4I0

Protein phosphatase 1 regulatory subunit 1B (Ppp1r1b)

32

22.9

88.3

111.7

0.0016

1.27

P19944

60S acidic ribosomal protein P1 (Rplp1)

57

11.5

87.9

112.1

0.047

1.28

A0A0G2KAY3

Kininogen-1 (Kng1)

12

44.2

87.4

112.6

0.00020

1.29

A0A0G2JSR6

Guanine nucleotide-binding protein subunit gamma (Gng7)

54

7.7

87.3

112.7

0.00080

1.29

P61459

Pterin-4-alpha-carbinolamine dehydratase (Pcbd1)

7

12

87.2

112.8

0.0020

1.29

B4F7E8

Niban-like protein 1 (Fam129b)

3

84.7

87.0

113.1

0.00050

1.30

F1M5V2

GLI pathogenesis-related 2 (Glipr2)

8

19

86.9

113.2

0.025

1.30

P19939

Apolipoprotein C-I (Apoc1)

10

9.9

86.8

113.2

0.011

1.30

Q5EBC0

Inter alpha-trypsin inhibitor, heavy chain 4 (Itih4)

9

103.7

86.7

113.3

< 0.0001

1.31

G3V8T7

RCG51933, isoform CRA_a (Tdrkh)

4

62

86.3

113.8

0.031

1.32

P47727

Carbonyl reductase [NADPH] 1 (Cbr1)

39

30.6

86.1

113.9

0.0052

1.32

A0A0G2JVX7

Apolipoprotein A-IV (Apoa4)

23

44.3

85.8

114.2

0.00020

1.33

P04094

Proenkephalin-A (Penk)

12

30.9

85.7

114.3

0.0010

1.33

A0A0G2JZB6

Uncharacterized protein

12

15.8

85.6

114.4

0.029

1.34

P02764

Alpha-1-acid glycoprotein (Orm1)

11

23.6

85.4

114.6

< 0.0001

1.34

P62749

Hippocalcin-like protein 1 (Hpcal1)

26

22.3

85.4

114.6

0.00080

1.34

P04177

Tyrosine 3-monooxygenase (Th)

28

55.9

85.3

114.7

< 0.0001

1.34

D3ZTN0

Protein kinase, DNA-activated, catalytic polypeptide (Prkdc)

0

471.8

85.2

114.8

0.010

1.35

Q00495

Macrophage colony-stimulating factor 1 receptor (Csf1r)

1

109.2

85.2

114.8

0.031

1.35

G3V7X2

Scg2 protein (Scg2)

4

66.6

85.1

114.9

0.0023

1.35

Q9QYU4

Ketimine reductase mu-crystallin (Crym)

39

33.5

85.0

115.1

< 0.0001

1.35

P07150

Annexin A1 (Anxa1)

17

38.8

84.9

115.1

0.0034

1.35

A0A0G2JZV3

ATP/GTP-binding protein 1 (Agtpbp1)

3

136.5

84.8

115.2

0.0061

1.36

Q68FY4

Group specific component (Gc)

28

53.5

84.8

115.2

< 0.0001

1.36

Q64240

Protein AMBP (Ambp)

8

38.8

84.8

115.2

0.00020

1.36

A0A0G2K3G0

Histidine-rich glycoprotein (Hrg)

4

60.3

84.7

115.3

0.0031

1.36

P08934

Kininogen-1 (Kng1)

5

70.9

84.6

115.4

0.028

1.37

Q9QX79

Fetuin-B (Fetub)

15

41.5

84.4

115.6

0.00010

1.37

F1M609

Acyl-coenzyme A oxidase (Acox1)

3

66

84.3

115.7

0.0086

1.37

A0A0G2K9I6

Ceruloplasmin (Cp)

10

123.6

83.8

116.2

< 0.0001

1.39

D3ZY96

Neutrophilic granule protein (Ngp)

20

19.4

83.8

116.2

0.0052

1.39

Q07936

Annexin A2 (Anxa2)

12

38.7

83.8

116.2

< 0.0001

1.39

D3ZGF1

CD44 antigen (Cd44)

7

52.8

83.7

116.3

0.0001

1.39

G3V6X7

ProSAAS (LOC108348172)

13

27.5

83.7

116.4

0.0021

1.39

M0R3N4

Vesicle amine transport 1-like (Vat1l)

22

41.6

83.6

116.4

< 0.0001

1.39

Q5M878

Serum amyloid A protein (Saa4)

15

15

83.5

116.5

0.00010

1.39

Q5M818

39S ribosomal protein L16, mitochondrial (Mrpl16)

6

28.9

83.4

116.6

0.031

1.40

A0A0G2JWX4

Keratin, type II cytoskeletal 2 epidermal (Krt2)

6

69.1

83.4

116.6

< 0.0001

1.40

Q63433

Serine/threonine-protein kinase N1 (Pkn1)

1

104.4

83.2

116.8

0.0027

1.40

A0A0G2K526

Guanine nucleotide-binding protein G(olf) subunit alpha (Gnal)

9

51.3

83.0

117.0

0.00010

1.41

P97738

Neuronal pentraxin-2 (Nptx2)

18

47.4

82.8

117.2

0.00010

1.42

P20761

Ig gamma-2B chain C region (Igh-1a)

7

36.5

82.2

117.8

< 0.0001

1.43

A0A0G2JYK0

Serine protease inhibitor A3N (LOC299282)

27

67.9

81.8

118.2

< 0.0001

1.44

Q63910

Alpha globin (Hba-a3)

15

15.5

81.8

118.3

0.0056

1.45

P47728

Calretinin (Calb2)

15

31.4

81.2

118.9

< 0.0001

1.46

P01355

Cholecystokinin (Cck)

9

12.8

80.9

119.1

0.0029

1.47

D3ZQN7

Laminin subunit beta 1 (Lamb1)

1

197.3

80.8

119.2

0.038

1.48

D4AA52

Murinoglobulin-1 (LOC297568)

13

163.6

80.7

119.3

< 0.0001

1.48

P01048

T-kininogen 1 (Map1)

6

47.7

80.7

119.3

0.012

1.48

Q4FZU2

Keratin, type II cytoskeletal 6A (Krt6a)

7

59.2

80.4

119.7

0.017

1.49

P06866

Haptoglobin (Hp)

19

38.5

80.3

119.7

< 0.0001

1.49

Q5I0M1

Apolipoprotein H (Apoh)

11

38.4

80.3

119.8

0.011

1.49

Q6IFW6

Keratin, type I cytoskeletal 10 (Krt10)

13

56.5

80.2

119.8

< 0.0001

1.49

A0A0G2QC06

Serotransferrin (Tf)

24

107.3

80.1

120.0

< 0.0001

1.50

P02767

Transthyretin (Ttr)

20

15.7

79.8

120.2

0.00010

1.51

F7FHF3

Serpin family F member 2 (Serpinf2)

5

62.3

79.6

120.5

0.00010

1.51

D3ZFH5

Inter-alpha-trypsin inhibitor heavy chain 2 (Itih2)

4

92.3

79.4

120.6

< 0.0001

1.52

Q68G38

Torsin-1A (Tor1a)

3

37.9

79.3

120.7

0.034

1.52

A0A0G2JUX5

Transcriptional activator protein Pur-beta (Purb)

24

33.5

79.3

120.7

< 0.0001

1.52

P20156

Neurosecretory protein VGF (Vgf)

21

68.1

78.7

121.3

0.026

1.54

M0RBF1

Complement C3 (C3)

21

186.2

78.6

121.5

< 0.0001

1.55

P00697

Lysozyme C-1 (Lyz1)

16

16.7

77.4

122.6

0.00040

1.58

A0A0G2JZ73

Alpha-1-antiproteinase (Serpina1)

39

46.6

77.4

122.6

< 0.0001

1.59

Q62930

Complement component C9 (C9)

2

62.2

77.3

122.8

0.00010

1.59

Q6P6Q2

Keratin, type II cytoskeletal 5 (Krt5)

15

61.8

77.1

122.9

< 0.0001

1.59

G3V9R9

Afamin (Afm)

15

69.2

76.9

123.2

< 0.0001

1.60

P24090

Alpha-2-HS-glycoprotein (Ahsg)

26

38

76.6

123.4

< 0.0001

1.61

P20059

Hemopexin (Hpx)

23

51.3

76.5

123.6

< 0.0001

1.62

A0A0G2JSK1

RCG20603 (Serpina3c)

28

46.4

76.3

123.7

< 0.0001

1.62

A0A0H2UHJ1

Protein S100-A9 (S100a9)

11

15.2

76.0

124.0

< 0.0001

1.63

Q6IMF3

Keratin, type II cytoskeletal 1 (Krt1)

8

64.8

75.7

124.3

< 0.0001

1.64

F7F8G2

Bromodomain testis-specific protein (Brdt)

1

106.7

75.6

124.4

< 0.0001

1.65

P12346

Serotransferrin (Tf)

31

76.3

75.3

124.7

0.00010

1.66

D3ZJF8

Fc fragment of IgG-binding protein (Fcgbp)

0

275

75.2

124.9

< 0.0001

1.66

A0A0H2UHI5

Serine protease inhibitor A3N (Serpina3n)

24

45.5

74.4

125.6

< 0.0001

1.69

Q63041

Alpha-1-macroglobulin (A1m)

10

167

74.4

125.7

< 0.0001

1.69

P10959

Carboxylesterase 1C (Ces1c)

11

60.1

74.2

125.9

< 0.0001

1.70

Q03626

Murinoglobulin-1 (Mug1)

13

165.2

73.7

126.3

< 0.0001

1.71

Q5BJY9

Keratin, type I cytoskeletal 18 (Krt18)

6

47.7

73.6

126.4

0.00040

1.72

A0A0H2UI36

Uncharacterized protein

14

17

71.9

128.2

< 0.0001

1.78

P50115

Protein S100-A8 (S100a8)

22

10.2

71.6

128.4

< 0.0001

1.79

P42930

Heat shock protein beta-1 (Hspb1)

41

22.9

71.0

129.0

< 0.0001

1.82

Q6IFV1

Keratin, type I cytoskeletal 14 (Krt14)

15

52.7

70.8

129.2

< 0.0001

1.82

P04639

Apolipoprotein A-I (Apoa1)

41

30

70.8

129.2

< 0.0001

1.83

P02770

Serum albumin (Alb)

64

68.7

69.9

130.2

< 0.0001

1.86

Q62669

Globin a1 (LOC103694855)

46

16

68.8

131.2

< 0.0001

1.91

B0BNN3

Carbonic anhydrase 1 (Ca1)

8

28.3

67.7

132.3

0.00010

1.95

M0RCX0

Pterin-4 alpha-carbinolamine dehydratase 2 (Pcbd2)

22

14.1

66.4

133.6

0.039

2.01

P02091

Hemoglobin subunit beta-1 (Hbb)

82

16

64.3

135.7

< 0.0001

2.11

Q6IFU7

Keratin, type I cytoskeletal 42 (Krt42)

13

50.2

62.0

138.0

< 0.0001

2.22

P11517

Hemoglobin subunit beta-2 (Hbb2)

78

16

59.3

140.8

< 0.0001

2.38

P01946

Hemoglobin subunit alpha-1/2 (Hba1)

63

15.3

54.9

145.1

< 0.0001

2.64

A0A0G2JSH5

Serum albumin (Alb)

65

68.7

47.6

152.4

0.00010

3.21

F1LRV4

Heat shock 70 kDa protein 4 (Hspa4)

41

94

20.9

179.1

< 0.0001

8.56

  1. MW molecular weight, TBI traumatic brain injury, FC fold change
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Molecular Brain

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